BCL2

Across TCGA patient cohorts, BCL2 mutation is significantly associated with the RNA expression of many other genes, with 2,515 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCL2-associated genes across cancer lineages are RN7SL470P, RNU7-180P, and OR5F2P. Each is linked with BCL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL2-to-partner and partner-to-BCL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL470P grouped by BCL2-low versus BCL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL2→partner) and Y-score (partner→BCL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL470P →	+0.239	+2.042	<.001	.005	3	2
SKCM	RNU7-180P →	+0.452	+5.039	<.001	.003	3	2
SKCM	OR5F2P →	+0.030	+5.039	<.001	.003	3	2
SKCM	LINC01520 →	+0.035	+4.208	<.001	.003	3	2
LUAD	RNU6-131P →	+0.406	+6.444	<.001	.001	3	2
LUAD	BSNDP4 →	+0.128	+6.444	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,515 associations by consensus.

RN7SL470P by BCL2 expression — UCEC

Explore this box plot interactively →