BCL2

Across TCGA patient cohorts, BCL2 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCL2-associated genes across cancer lineages are Ku80, MEK1_p_S217_S221, and PDCD4. Each is linked with BCL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL2-to-partner and partner-to-BCL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by BCL2-low versus BCL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL2→partner) and Y-score (partner→BCL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.272	+2.472	.017	.011	3	1
UCEC	MEK1_p_S217_S221 →	-0.298	-3.169	.023	.019	3	1
UCEC	PDCD4 →	-0.626	-2.459	.005	.020	3	1
UCEC	PI3K-p85 →	+0.222	+2.999	.028	.035	3	1
UCEC	Tuberin →	+0.471	+3.584	<.001	.002	3	1
UCEC	p62 Lck ligand →	+0.400	+3.009	.010	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Ku80 by BCL2 expression — UCEC

Explore this box plot interactively →