BCL2

Across TCGA cell cohorts, BCL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,786 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible BCL2-associated GO terms across cancer lineages are DNA synthesis involved in DNA repair, Zymogen activation, and Metanephric proximal tubule development. Each is linked with BCL2 in more than 9 cancer types. Because this analysis shows association rather than direction, both BCL2-to-partner and partner-to-BCL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA synthesis involved in DNA repair grouped by BCL2-low versus BCL2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL2→partner) and Y-score (partner→BCL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	DNA synthesis involved in DNA repair →	+0.075	+1.248	<.001	<.001	3	10
OESOPHAGUS	Zymogen activation →	-0.204	-1.162	.002	<.001	3	9
OESOPHAGUS	Metanephric proximal tubule development →	+0.230	+0.976	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Defense response to bacterium →	-0.139	-0.689	<.001	.006	3	8
LUNG_SCLC	DNA strand elongation involved in DNA replication →	+0.146	+2.584	<.001	<.001	3	8
SOFT_TISSUE	Centrosome cycle →	+0.068	+0.987	.003	.007	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,786 associations by consensus.

DNA synthesis involved in DNA repair by BCL2 expression — BREAST

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