BCL2

Across TCGA cell cohorts, BCL2 mutation is significantly associated with the RNA expression of many other genes, with 508 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible BCL2-associated genes across cancer lineages are OR10K2, ZCCHC13, and GRXCR1. Each is linked with BCL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL2-to-partner and partner-to-BCL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10K2 grouped by BCL2-low versus BCL2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL2→partner) and Y-score (partner→BCL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10K2 →	+0.060	+4.705	<.001	.003	3	1
BLOOD_Leukemia	ZCCHC13 →	+0.022	+5.569	<.001	.001	3	1
BLOOD_Leukemia	GRXCR1 →	+0.017	+5.569	<.001	.001	3	1
BLOOD_Lymphoma	SYNGR1 →	+2.202	+3.321	<.001	.003	3	1
BLOOD_Lymphoma	APOL1 →	-1.704	-2.700	.005	.003	3	1
BLOOD_Lymphoma	IL2RB →	-2.858	-3.807	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 508 associations by consensus.

OR10K2 by BCL2 expression — BLOOD_Leukemia

Explore this box plot interactively →