BCL11B

Across TCGA patient cohorts, BCL11B mutation is significantly associated with the RNA expression of many other genes, with 5,072 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCL11B-associated genes across cancer lineages are PSMD9, PLGRKT, and MRPL18. Each is linked with BCL11B in more than 4 cancer types. Because this analysis shows association rather than direction, both BCL11B-to-partner and partner-to-BCL11B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMD9 grouped by BCL11B-low versus BCL11B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL11B→partner) and Y-score (partner→BCL11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PSMD9 →	+0.299	+2.638	.005	.005	3	5
COAD	PLGRKT →	+0.551	+3.713	.002	<.001	3	4
SKCM	MRPL18 →	+0.389	+2.350	<.001	<.001	3	4
UCEC	MRPS15 →	+0.274	+1.450	.003	<.001	3	4
UCEC	SDHB →	+0.348	+1.925	<.001	<.001	3	4
COAD	EXOSC9 →	+0.496	+3.713	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,072 associations by consensus.

PSMD9 by BCL11B expression — COAD

Explore this box plot interactively →