BCL11B

Across TCGA cell cohorts, BCL11B mutation is significantly associated with the RNA expression of many other genes, with 2,422 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BCL11B-associated genes across cancer lineages are OTC, F13B, and OR1C1. Each is linked with BCL11B in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL11B-to-partner and partner-to-BCL11B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OTC grouped by BCL11B-low versus BCL11B-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL11B→partner) and Y-score (partner→BCL11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OTC →	+1.361	+4.491	<.001	.003	3	2
CNS	F13B →	+0.071	+3.617	<.001	.006	3	2
CNS	OR1C1 →	+0.024	+3.700	.001	.003	3	2
SKIN	OR2D2 →	+0.031	+3.242	<.001	.003	3	2
BLOOD_Leukemia	KCTD17 →	+1.142	+3.290	.001	.003	3	2
LARGE_INTESTINE	POLDIP3 →	+0.576	+3.362	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,422 associations by consensus.

OTC by BCL11B expression — PANCREAS

Explore this box plot interactively →