BCL10

Across TCGA patient cohorts, BCL10 mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCL10-associated genes across cancer lineages are RNU1-48P, OR11H5P, and RN7SKP251. Each is linked with BCL10 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL10-to-partner and partner-to-BCL10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-48P grouped by BCL10-low versus BCL10-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL10→partner) and Y-score (partner→BCL10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU1-48P →	+0.199	+7.930	<.001	.008	3	2
BLCA	OR11H5P →	+0.059	+6.018	.003	.002	3	2
BRCA	RN7SKP251 →	+0.372	+4.580	<.001	.004	3	1
UCEC	PEDS1-UBE2V1 →	+0.040	+3.265	.001	.005	3	1
BRCA	RNU6-1149P →	+0.382	+4.423	.007	.006	3	1
BRCA	MIR548AK →	+0.673	+5.332	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

RNU1-48P by BCL10 expression — LUAD

Explore this box plot interactively →