BCKDK

Across TCGA patient cohorts, BCKDK mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCKDK-associated genes across cancer lineages are MEK1, Rad50, and 14-3-3_beta. Each is linked with BCKDK in more than 1 cancer types. Because this analysis shows association rather than direction, both BCKDK-to-partner and partner-to-BCKDK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by BCKDK-low versus BCKDK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCKDK→partner) and Y-score (partner→BCKDK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.290	+2.000	.043	.030	3	2
UCEC	Rad50 →	-0.292	-1.584	.002	.036	3	2
UCEC	14-3-3_beta →	-0.079	-2.432	.044	.018	3	1
UCEC	eIF4G →	+0.302	+2.000	.013	.010	3	1
UCEC	Fibronectin →	-0.289	-2.502	.025	.002	3	1
UCEC	ACC1 →	+0.390	+1.750	.006	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

MEK1 by BCKDK expression — UCEC

Explore this box plot interactively →