BCKDK

Across TCGA cell cohorts, BCKDK RNA expression is significantly associated with the go_rna of many other GO terms, with 3,895 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BCKDK-associated GO terms across cancer lineages are Isoleucine metabolic process, L-isoleucine catabolic process, and Canonical glycolysis. Each is linked with BCKDK in more than 12 cancer types. Because this analysis shows association rather than direction, both BCKDK-to-partner and partner-to-BCKDK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Isoleucine metabolic process grouped by BCKDK-low versus BCKDK-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BCKDK→partner) and Y-score (partner→BCKDK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Isoleucine metabolic process →	+0.169	+0.728	<.001	<.001	3	13
STOMACH	L-isoleucine catabolic process →	+0.169	+0.728	<.001	<.001	3	13
LARGE_INTESTINE	Canonical glycolysis →	+0.121	+0.967	<.001	<.001	3	11
LARGE_INTESTINE	Glucose catabolic process to pyruvate →	+0.121	+0.967	<.001	<.001	3	11
STOMACH	Anatomical structure homeostasis →	-0.068	-0.766	.008	.004	3	11
CNS	GDP-mannose biosynthetic process →	+0.126	+0.679	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,895 associations by consensus.

Isoleucine metabolic process by BCKDK expression — STOMACH

Explore this box plot interactively →