BCKDK

Across TCGA cell cohorts, BCKDK mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BCKDK-associated genes across cancer lineages are IQCF5, OR56A5, and TBC1D21. Each is linked with BCKDK in more than 1 cancer types. Because this analysis shows association rather than direction, both BCKDK-to-partner and partner-to-BCKDK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by BCKDK-low versus BCKDK-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCKDK→partner) and Y-score (partner→BCKDK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IQCF5 →	+0.124	+5.201	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	OR56A5 →	+0.045	+4.736	<.001	.009	3	1
LARGE_INTESTINE	TBC1D21 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	XKR3 →	+0.033	+3.793	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

IQCF5 by BCKDK expression — BLOOD_Leukemia

Explore this box plot interactively →