BCKDHA

Across TCGA patient cohorts, BCKDHA mutation is significantly associated with the RNA expression of many other genes, with 2,557 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCKDHA-associated genes across cancer lineages are RN7SL643P, RN7SL465P, and RARRES2P5. Each is linked with BCKDHA in more than 2 cancer types. Because this analysis shows association rather than direction, both BCKDHA-to-partner and partner-to-BCKDHA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL643P grouped by BCKDHA-low versus BCKDHA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCKDHA→partner) and Y-score (partner→BCKDHA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL643P →	+0.068	+4.578	<.001	<.001	3	3
HNSC	RN7SL465P →	+0.191	+5.339	<.001	.003	3	3
HNSC	RARRES2P5 →	+0.343	+4.346	<.001	.007	3	3
SKCM	RNA5SP286 →	+0.098	+4.315	<.001	.005	3	3
STAD	CCNG2P1 →	+0.091	+4.219	.007	.009	3	3
STAD	MIR3922 →	+0.734	+4.290	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,557 associations by consensus.

RN7SL643P by BCKDHA expression — SKCM

Explore this box plot interactively →