BCKDHA

Across TCGA patient cohorts, BCKDHA mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCKDHA-associated genes across cancer lineages are eEF2, ERK2, and Acetyl-a-Tubulin-Lys40. Each is linked with BCKDHA in more than 2 cancer types. Because this analysis shows association rather than direction, both BCKDHA-to-partner and partner-to-BCKDHA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by BCKDHA-low versus BCKDHA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCKDHA→partner) and Y-score (partner→BCKDHA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.375	+3.169	.011	.018	3	2
UCEC	ERK2 →	+0.230	+2.459	.003	.018	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.529	+2.321	.011	.006	3	2
COAD	MSH2 →	-0.418	-3.313	<.001	.010	3	2
UCEC	N-Ras →	-0.123	-2.302	.012	.034	3	2
UCEC	p21 →	+0.157	+3.321	.048	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

eEF2 by BCKDHA expression — UCEC

Explore this box plot interactively →