BCKDHA

Across TCGA cell cohorts, BCKDHA RNA expression is significantly associated with the go_rna of many other GO terms, with 2,515 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BCKDHA-associated GO terms across cancer lineages are Branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA, Branched-chain amino acid metabolic process, and Branched-chain amino acid catabolic process. Each is linked with BCKDHA in more than 15 cancer types. Because this analysis shows association rather than direction, both BCKDHA-to-partner and partner-to-BCKDHA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA grouped by BCKDHA-low versus BCKDHA-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BCKDHA→partner) and Y-score (partner→BCKDHA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA →	+0.167	+1.520	<.001	<.001	3	16
OVARY	Branched-chain amino acid metabolic process →	+0.104	+1.100	<.001	<.001	3	10
OVARY	Branched-chain amino acid catabolic process →	+0.098	+1.274	<.001	<.001	3	10
LUNG_NSCLC_LUAD	Succinyl-CoA biosynthetic process →	+0.102	+0.878	.001	<.001	3	8
BLOOD_Leukemia	Positive regulation of endosome organization →	+0.176	+0.708	<.001	<.001	3	8
STOMACH	Regulation of base-excision repair →	+0.147	+0.997	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,515 associations by consensus.

Branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA by BCKDHA expression — OESOPHAGUS

Explore this box plot interactively →