BCKDHA

Across TCGA cell cohorts, BCKDHA mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BCKDHA-associated genes across cancer lineages are PRR27, OR7A10, and LEFTY2. Each is linked with BCKDHA in more than 1 cancer types. Because this analysis shows association rather than direction, both BCKDHA-to-partner and partner-to-BCKDHA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR27 grouped by BCKDHA-low versus BCKDHA-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCKDHA→partner) and Y-score (partner→BCKDHA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PRR27 →	+0.091	+4.029	<.001	.009	3	2
SKIN	OR7A10 →	+0.011	+4.022	<.001	.006	3	1
SKIN	LEFTY2 →	+0.054	+4.614	<.001	<.001	3	1
SKIN	OR13D1 →	+0.019	+3.345	<.001	.007	3	1
OVARY	RBMY1A1 →	+0.107	+4.807	<.001	.003	3	1
OVARY	VSIG10L2 →	+0.265	+4.029	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

PRR27 by BCKDHA expression — OVARY

Explore this box plot interactively →