BCHE

Across TCGA cell cohorts, BCHE mutation is significantly associated with the mutation status of many other genes, with 3,932 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BCHE-associated genes across cancer lineages are RBM47, FLNB, and WDR33. Each is linked with BCHE in more than 4 cancer types. Because this analysis shows association rather than direction, both BCHE-to-partner and partner-to-BCHE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBM47 grouped by BCHE-low versus BCHE-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCHE→partner) and Y-score (partner→BCHE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RBM47 →	+5.044	+5.614	.003	.003	1	5
BLOOD_Leukemia	FLNB →	+2.260	+3.101	.002	.002	1	5
BONE	WDR33 →	+5.000	+4.437	.007	.007	1	4
BONE	LRFN2 →	+5.000	+4.437	.007	.007	1	4
BONE	KIT →	+5.000	+4.437	.007	.007	1	4
BONE	ATAD5 →	+5.000	+4.437	.007	.007	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,932 associations by consensus.

RBM47 by BCHE expression — CNS

Explore this box plot interactively →