BCAT2

Across TCGA patient cohorts, BCAT2 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCAT2-associated genes across cancer lineages are Fibronectin, MSH6, and eIF4E. Each is linked with BCAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCAT2-to-partner and partner-to-BCAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by BCAT2-low versus BCAT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCAT2→partner) and Y-score (partner→BCAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.271	-2.212	.032	.010	3	2
UCEC	MSH6 →	-0.330	-2.459	.009	.018	3	2
UCEC	eIF4E →	+0.166	+3.183	.040	.009	3	1
UCEC	ERK2 →	+0.182	+2.584	.014	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.171	-2.584	.008	.010	3	1
UCEC	JNK2 →	+0.198	+3.026	.009	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Fibronectin by BCAT2 expression — UCEC

Explore this box plot interactively →