BCAT1

Across TCGA pan-cancer cohorts, BCAT1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of BCAT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where BCAT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BCAT1 is over-expressed in tumor, although a few such as PAAD and READ show the opposite, repressed pattern.

HNSC, KIRC, and THCA are the cancer types where BCAT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BCAT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+2.698	<.001	12	view →
KIRC	Male	IV	+1.232	<.001	11	view →
THCA	All	All	+0.739	<.001	8	view →
LIHC	All	II,III,IV	+0.700	<.001	8	view →
KICH	All	II,III,IV	+1.702	<.001	6	view →
BRCA	Female	II,III,IV	+0.658	<.001	6	view →
CHOL	All	All	+1.443	.003	5	view →
BLCA	All	All	+0.835	.026	4	view →
STAD	All	All	+0.821	.006	4	view →
PAAD	Male	All	−1.029	.019	2	view →
KIRP	Male	All	+0.734	.011	2	view →
READ	Female	All	−0.863	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

BCAT1–HNSC

Open the HNSC breakdown →