BCAS4

Across TCGA patient cohorts, BCAS4 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCAS4-associated genes across cancer lineages are PDCD4, Cyclin-E2, and Di-Ras3. Each is linked with BCAS4 in more than 2 cancer types. Because this analysis shows association rather than direction, both BCAS4-to-partner and partner-to-BCAS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by BCAS4-low versus BCAS4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCAS4→partner) and Y-score (partner→BCAS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.811	-3.169	<.001	.018	3	2
UCEC	Cyclin-E2 →	+0.223	+3.009	.006	.019	3	2
UCEC	Di-Ras3 →	-0.185	-2.459	.009	.020	2	3
UCEC	EGFR_pY1068 →	-0.301	-3.584	.013	.002	3	1
UCEC	eIF4E →	+0.213	+3.584	.036	.002	3	1
UCEC	A-Raf_pS299 →	-0.154	-3.169	.007	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

PDCD4 by BCAS4 expression — UCEC

Explore this box plot interactively →