BCAS1

Across TCGA patient cohorts, BCAS1 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCAS1-associated genes across cancer lineages are Cyclin-B1, FoxM1, and PCNA. Each is linked with BCAS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both BCAS1-to-partner and partner-to-BCAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by BCAS1-low versus BCAS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCAS1→partner) and Y-score (partner→BCAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.676	+2.736	.001	<.001	3	3
SKCM	FoxM1 →	+0.235	+2.459	.008	.018	3	2
UCEC	PCNA →	+0.421	+3.392	<.001	<.001	2	3
SKCM	Rb →	-0.163	-2.115	.018	.018	3	2
SKCM	c-Met →	-0.128	-2.098	.043	.018	3	2
UCEC	eEF2 →	+0.344	+2.584	.008	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Cyclin-B1 by BCAS1 expression — UCEC

Explore this box plot interactively →