BCAR1

Across TCGA patient cohorts, BCAR1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCAR1-associated genes across cancer lineages are ERK2, Shc_pY317, and Src_pY416. Each is linked with BCAR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCAR1-to-partner and partner-to-BCAR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by BCAR1-low versus BCAR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCAR1→partner) and Y-score (partner→BCAR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.162	+2.115	.025	.017	3	2
UCEC	Shc_pY317 →	-0.183	-1.415	.001	.046	3	2
UCEC	Src_pY416 →	-0.226	-3.459	.012	.005	3	2
SKCM	HER3 →	-0.496	-3.152	.027	.019	3	1
SKCM	Notch1 →	-0.252	-2.987	.016	.035	3	1
UCEC	14-3-3_beta →	-0.082	-1.401	.028	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

ERK2 by BCAR1 expression — UCEC

Explore this box plot interactively →