BBX

Across TCGA pan-cancer cohorts, BBX mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated BBX data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher BBX mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated BBX expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

PDAC, HNSC, and UCEC are the cancer types where BBX mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	III,IV	0.942	0.376	<.001	26	view →
HNSC	OS	Median	All	0.344	1.000	.009	24	view →
UCEC	DFS	Median	II,III,IV	0.809	1.000	.030	10	view →
CCRCC	OS	Median	III,IV	0.842	1.000	.041	6	view →
GBM	DFS	Median	All	0.654	0.836	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

BBX–PDAC (DFS)

Open the PDAC breakdown →