BBX

Across TCGA patient cohorts, BBX protein abundance is significantly associated with the RNA expression of many other genes, with 8,509 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BBX-associated genes across cancer lineages are NEPRO, DZIP3, and KRT8P12. Each is linked with BBX in more than 3 cancer types. Because this analysis shows association rather than direction, both BBX-to-partner and partner-to-BBX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BBX versus NEPRO in HNSC, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBX→partner) and Y-score (partner→BBX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NEPRO →	+0.791	+0.269	<.001	.003	3	4
HNSC	DZIP3 →	+0.721	+0.272	.001	.002	3	4
HNSC	KRT8P12 →	+0.763	+0.270	<.001	.006	3	4
HNSC	ASTE1 →	+0.734	+0.337	<.001	<.001	3	4
PDAC	METTL11B →	-0.618	-0.282	<.001	<.001	3	3
HNSC	SULT2B1 →	-1.429	-0.323	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,509 associations by consensus.

BBX vs NEPRO — HNSC

Explore this scatter interactively →