BBX

Across TCGA patient cohorts, BBX mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BBX-associated genes across cancer lineages are Cyclin-B1, p90 RSK, and Caspase-7-cleavedD198. Each is linked with BBX in more than 3 cancer types. Because this analysis shows association rather than direction, both BBX-to-partner and partner-to-BBX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by BBX-low versus BBX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBX→partner) and Y-score (partner→BBX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.580	+3.807	<.001	<.001	3	4
STAD	p90 RSK →	+0.314	+3.169	.011	.019	3	3
COAD	Caspase-7-cleavedD198 →	+1.888	+2.815	<.001	.036	3	3
UCEC	FASN →	+0.318	+1.362	.009	.034	3	2
UCEC	STAT3_pY705 →	-0.296	-1.415	<.001	.010	3	2
UCEC	Tuberin →	+0.286	+1.999	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Cyclin-B1 by BBX expression — UCEC

Explore this box plot interactively →