BBS9

Across TCGA patient cohorts, BBS9 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BBS9-associated genes across cancer lineages are c-Kit, Cyclin-B1, and HER2. Each is linked with BBS9 in more than 1 cancer types. Because this analysis shows association rather than direction, both BBS9-to-partner and partner-to-BBS9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by BBS9-low versus BBS9-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBS9→partner) and Y-score (partner→BBS9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	c-Kit →	-0.466	-3.000	.028	.035	3	2
BLCA	Cyclin-B1 →	+0.517	+2.999	.018	.035	3	2
LUSC	HER2 →	+0.515	+2.179	.003	.035	3	2
LUSC	TFRC →	+0.843	+3.331	.009	.005	3	2
UCEC	GSK-3a-b_pS21_S9 →	+0.332	+1.415	.038	.046	3	2
UCEC	ACC1 →	+0.301	+3.335	.027	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

c-Kit by BBS9 expression — LUSC

Explore this box plot interactively →