BBS9

Across TCGA cell cohorts, BBS9 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BBS9-associated genes across cancer lineages are DRD3, GZMA, and VSIG4. Each is linked with BBS9 in more than 1 cancer types. Because this analysis shows association rather than direction, both BBS9-to-partner and partner-to-BBS9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DRD3 grouped by BBS9-low versus BBS9-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBS9→partner) and Y-score (partner→BBS9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DRD3 →	+0.006	+5.614	<.001	.002	3	1
SKIN	GZMA →	+0.127	+3.743	<.001	.001	3	1
SKIN	VSIG4 →	+0.011	+3.084	<.001	.002	3	1
SKIN	C1QC →	+0.021	+3.781	<.001	<.001	3	1
SKIN	ZNF705G →	+0.020	+2.882	<.001	.005	3	1
LARGE_INTESTINE	SH3GL2 →	+1.381	+3.474	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

DRD3 by BBS9 expression — PANCREAS

Explore this box plot interactively →