BBS7

Across TCGA patient cohorts, BBS7 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BBS7-associated genes across cancer lineages are S6_pS240_S244, p62 Lck ligand, and Akt_pT308. Each is linked with BBS7 in more than 3 cancer types. Because this analysis shows association rather than direction, both BBS7-to-partner and partner-to-BBS7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by BBS7-low versus BBS7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBS7→partner) and Y-score (partner→BBS7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.289	+1.662	.044	.011	3	4
UCEC	p62 Lck ligand →	+0.302	+2.817	.008	.001	3	2
UCEC	Akt_pT308 →	+0.441	+2.459	.047	.018	3	2
UCEC	C-Raf →	+0.133	+2.222	.008	.010	3	2
UCEC	GSK-3a-b_pS21_S9 →	+0.380	+1.331	.011	.043	3	1
UCEC	Myosin-IIa_pS1943 →	+0.221	+1.676	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

S6_pS240_S244 by BBS7 expression — UCEC

Explore this box plot interactively →