BBS7

Across TCGA cell cohorts, BBS7 mutation is significantly associated with the drug of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BBS7-associated genes across cancer lineages are GSK3337463A, Wnt-C59, and GSK2801. Each is linked with BBS7 in more than 1 cancer types. Because this analysis shows association rather than direction, both BBS7-to-partner and partner-to-BBS7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK3337463A grouped by BBS7-low versus BBS7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBS7→partner) and Y-score (partner→BBS7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSK3337463A →	+0.367	+2.649	.031	.046	3	1
LARGE_INTESTINE	Wnt-C59 →	+0.405	+2.678	.020	.037	2	1
LARGE_INTESTINE	GSK2801 →	+0.321	+2.649	.044	.046	1	1
LARGE_INTESTINE	IRAK4_4710 →	+0.398	+2.649	.028	.046	1	1
LARGE_INTESTINE	Acetalax →	+0.748	+2.649	.023	.046	1	1
LARGE_INTESTINE	Teniposide →	+0.644	+2.649	.015	.046	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

GSK3337463A by BBS7 expression — LARGE_INTESTINE

Explore this box plot interactively →