BBS5

Across TCGA patient cohorts, BBS5 protein abundance is significantly associated with the RNA expression of many other genes, with 2,319 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BBS5-associated genes across cancer lineages are RGS22, GCH1, and ATP13A3. Each is linked with BBS5 in more than 2 cancer types. Because this analysis shows association rather than direction, both BBS5-to-partner and partner-to-BBS5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BBS5 versus RGS22 in BRCA, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBS5→partner) and Y-score (partner→BBS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RGS22 →	+2.291	+0.727	.005	.004	3	3
UCEC	GCH1 →	-0.890	-0.632	.001	.002	3	2
UCEC	ATP13A3 →	-0.696	-0.763	<.001	<.001	3	2
LUAD	PSAT1 →	-1.318	-0.359	<.001	.009	3	2
BRCA	SAMD15 →	+2.124	+1.077	<.001	<.001	3	2
BRCA	CEP126 →	+1.850	+0.958	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,319 associations by consensus.

BBS5 vs RGS22 — BRCA

Explore this scatter interactively →