BBS5

Across TCGA patient cohorts, BBS5 mutation is significantly associated with the RNA expression of many other genes, with 1,685 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BBS5-associated genes across cancer lineages are MIR1273H, KIR3DL1, and ATP5MC1P1. Each is linked with BBS5 in more than 2 cancer types. Because this analysis shows association rather than direction, both BBS5-to-partner and partner-to-BBS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1273H grouped by BBS5-low versus BBS5-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBS5→partner) and Y-score (partner→BBS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR1273H →	+0.316	+4.653	<.001	.007	3	3
UCEC	KIR3DL1 →	+0.163	+2.026	.004	.002	3	2
COAD	ATP5MC1P1 →	+0.211	+3.452	.001	.009	3	2
COAD	ATP5F1AP1 →	+0.053	+4.169	.003	.001	3	2
LUAD	LINC01075 →	+0.150	+5.888	<.001	.002	3	2
UCEC	RNA5SP415 →	+0.799	+2.788	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,685 associations by consensus.

MIR1273H by BBS5 expression — READ

Explore this box plot interactively →