BBS5

Across TCGA patient cohorts, BBS5 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BBS5-associated genes across cancer lineages are Shc_pY317, Di-Ras3, and eIF4G. Each is linked with BBS5 in more than 1 cancer types. Because this analysis shows association rather than direction, both BBS5-to-partner and partner-to-BBS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by BBS5-low versus BBS5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBS5→partner) and Y-score (partner→BBS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.132	-1.584	.027	.036	3	2
UCEC	Di-Ras3 →	-0.174	-3.446	.002	.005	3	2
UCEC	eIF4G →	+0.267	+2.459	.028	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.166	-1.571	.011	.036	3	1
UCEC	Ku80 →	+0.267	+2.009	.004	.017	3	1
UCEC	MEK1 →	+0.422	+2.700	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Shc_pY317 by BBS5 expression — UCEC

Explore this box plot interactively →