BBS12

Across TCGA patient cohorts, BBS12 mutation is significantly associated with the RNA expression of many other genes, with 5,269 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BBS12-associated genes across cancer lineages are POLR3G, YBX1P10, and ITFG2-AS1. Each is linked with BBS12 in more than 2 cancer types. Because this analysis shows association rather than direction, both BBS12-to-partner and partner-to-BBS12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLR3G grouped by BBS12-low versus BBS12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBS12→partner) and Y-score (partner→BBS12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POLR3G →	+0.332	+2.201	.005	.001	3	3
UCEC	YBX1P10 →	+0.542	+1.856	.007	.004	3	3
UCEC	ITFG2-AS1 →	+0.410	+1.946	<.001	<.001	3	3
READ	MIR4774 →	+0.841	+6.257	<.001	.001	3	2
SKCM	SMAD2 →	+0.468	+3.379	.004	.005	3	2
SKCM	SECISBP2 →	+0.676	+3.328	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,269 associations by consensus.

POLR3G by BBS12 expression — UCEC

Explore this box plot interactively →