BBS12

Across TCGA patient cohorts, BBS12 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BBS12-associated genes across cancer lineages are eEF2, GAPDH, and 4E-BP1. Each is linked with BBS12 in more than 3 cancer types. Because this analysis shows association rather than direction, both BBS12-to-partner and partner-to-BBS12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by BBS12-low versus BBS12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBS12→partner) and Y-score (partner→BBS12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.257	+1.321	.032	.029	3	4
UCEC	GAPDH →	+0.465	+1.906	.009	.014	3	4
UCEC	4E-BP1 →	+0.306	+2.201	<.001	<.001	3	3
UCEC	eIF4E →	+0.145	+2.472	.040	.010	3	2
UCEC	Notch1 →	+0.147	+1.594	.001	.021	3	2
UCEC	PCNA →	+0.214	+2.087	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

eEF2 by BBS12 expression — UCEC

Explore this box plot interactively →