BBS12

Across TCGA cell cohorts, BBS12 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible BBS12-associated genes across cancer lineages are LCE1A, CFAP97D2, and TBL1Y. Each is linked with BBS12 in more than 1 cancer types. Because this analysis shows association rather than direction, both BBS12-to-partner and partner-to-BBS12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE1A grouped by BBS12-low versus BBS12-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBS12→partner) and Y-score (partner→BBS12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LCE1A →	+0.126	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	CFAP97D2 →	+0.020	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	TBL1Y →	+0.053	+4.643	<.001	.008	3	1
BLOOD_Leukemia	AMELX →	+0.045	+5.539	<.001	.003	3	1
BLOOD_Leukemia	MYMK →	+0.031	+4.922	<.001	.009	3	1
LARGE_INTESTINE	OR4F21 →	+0.121	+3.141	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

LCE1A by BBS12 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →