BBS10

Across TCGA patient cohorts, BBS10 mutation is significantly associated with the RNA expression of many other genes, with 3,851 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BBS10-associated genes across cancer lineages are KRTAP12-1, KRTAP9-8, and ZNF92P1Y. Each is linked with BBS10 in more than 1 cancer types. Because this analysis shows association rather than direction, both BBS10-to-partner and partner-to-BBS10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP12-1 grouped by BBS10-low versus BBS10-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBS10→partner) and Y-score (partner→BBS10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	KRTAP12-1 →	+0.535	+5.418	<.001	.005	3	2
CESC	KRTAP9-8 →	+0.177	+5.306	<.001	.006	3	2
BLCA	ZNF92P1Y →	+0.014	+4.722	<.001	.003	3	2
BLCA	IMP3P2 →	+0.159	+2.856	<.001	.007	3	2
UCEC	ACAP3 →	+0.418	+1.922	.001	.009	3	2
UCEC	DPH7 →	+0.443	+2.305	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,851 associations by consensus.

KRTAP12-1 by BBS10 expression — CESC

Explore this box plot interactively →