BBOX1

Across TCGA pan-cancer cohorts, BBOX1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated BBOX1 data layer compared with 25 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher BBOX1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated BBOX1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and SKCM show a favorable association.

LUSC, ESCA, and LUAD are the cancer types where BBOX1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.112	0.733	<.001	12	view →
ESCA	OS	Median	All	0.147	0.700	.002	6	view →
LUAD	OS	Median	II,III,IV	0.090	0.677	<.001	6	view →
SCLC	DFS	Median	III,IV	1.000	0.197	.038	4	view →
SKCM	DFS	Median	II,III,IV	1.000	0.668	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

BBOX1–LUSC (OS)

Open the LUSC breakdown →