BBOX1

Across TCGA patient cohorts, BBOX1 mutation is significantly associated with the RNA expression of many other genes, with 923 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BBOX1-associated genes across cancer lineages are GPATCH11, AIMP1, and ATG16L1. Each is linked with BBOX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BBOX1-to-partner and partner-to-BBOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPATCH11 grouped by BBOX1-low versus BBOX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBOX1→partner) and Y-score (partner→BBOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GPATCH11 →	+0.552	+3.595	.002	.001	3	2
UCEC	AIMP1 →	+0.687	+3.606	<.001	.001	3	2
SKCM	ATG16L1 →	+0.501	+3.732	.007	<.001	3	2
BLCA	MTATP6P29 →	+0.118	+4.718	<.001	.003	3	2
STAD	RNA5SP405 →	+0.376	+4.090	<.001	.004	3	2
BLCA	ARL6IP1P3 →	+0.106	+4.292	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 923 associations by consensus.

GPATCH11 by BBOX1 expression — UCEC

Explore this box plot interactively →