BBOX1

Across TCGA cell cohorts, BBOX1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible BBOX1-associated genes across cancer lineages are PIP, MRAP, and KRT73. Each is linked with BBOX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BBOX1-to-partner and partner-to-BBOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIP grouped by BBOX1-low versus BBOX1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBOX1→partner) and Y-score (partner→BBOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PIP →	+0.185	+4.273	<.001	.006	3	1
SKIN	MRAP →	+0.032	+4.930	<.001	.001	3	1
SKIN	KRT73 →	+0.025	+4.467	<.001	.004	3	1
SKIN	IFNA7 →	+0.103	+4.273	<.001	.006	3	1
SKIN	IFNA17 →	+0.025	+4.930	<.001	.001	3	1
BLOOD_Lymphoma	SELE →	+0.050	+4.350	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PIP by BBOX1 expression — SKIN

Explore this box plot interactively →