BBC3

Across TCGA patient cohorts, BBC3 mutation is significantly associated with the RNA expression of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BBC3-associated genes across cancer lineages are IL9, MT4, and MRGPRX1. Each is linked with BBC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BBC3-to-partner and partner-to-BBC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL9 grouped by BBC3-low versus BBC3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBC3→partner) and Y-score (partner→BBC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	IL9 →	+0.414	+5.037	<.001	.009	3	2
SCLC	MT4 →	+0.378	+5.624	<.001	.003	3	1
SCLC	MRGPRX1 →	+0.596	+5.189	<.001	.006	3	1
BLCA	SNORD115-4 →	+0.428	+7.640	<.001	.009	3	1
UCEC	SLC20A1P2 →	+0.047	+4.538	.002	.006	3	1
UCEC	IGKV1OR1-1 →	+0.358	+4.993	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

IL9 by BBC3 expression — SKCM

Explore this box plot interactively →