BBC3

Across TCGA patient cohorts, BBC3 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BBC3-associated genes across cancer lineages are CD8+ T-cells, CD8+ Tcm, and Macrophages. Each is linked with BBC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BBC3-to-partner and partner-to-BBC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ T-cells grouped by BBC3-low versus BBC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBC3→partner) and Y-score (partner→BBC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8+ T-cells →	+0.055	+4.430	<.001	.002	3	2
UCEC	CD8+ Tcm →	+0.129	+4.520	<.001	.001	3	2
UCEC	Macrophages →	+0.028	+3.487	.013	.018	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CD8+ T-cells by BBC3 expression — UCEC

Explore this box plot interactively →