BARX2

Across TCGA pan-cancer cohorts, BARX2 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated BARX2 data layer compared with 1 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher BARX2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated BARX2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LIHC show a favorable association.

UCEC, UVM, and BLCA are the cancer types where BARX2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.259	0.710	.001	136	view →
UVM	OS	Tertile	All	0.371	0.764	<.001	111	view →
BLCA	DFS	Quartile	IV	0.191	0.707	<.001	80	view →
KIRC	OS	Median	All	0.696	0.565	<.001	65	view →
PAAD	DFS	Median	All	0.248	0.496	.001	38	view →
ACC	DFS	Quartile	II,III,IV	0.124	0.700	.004	34	view →
LAML	DFS	Quartile	All	0.185	0.517	.014	20	view →
LUSC	DFS	Tertile	III,IV	0.513	0.754	.018	18	view →
LIHC	DFS	Quartile	III,IV	0.648	0.155	.012	18	view →
ESCA	DFS	Tertile	IV	0.704	0.226	.024	14	view →
LUAD	OS	Tertile	All	0.248	0.416	.003	12	view →
UCS	DFS	Tertile	II,III,IV	0.561	0.149	.019	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

BARX2–UCEC (DFS)

Open the UCEC breakdown →