BARX1

Across TCGA pan-cancer cohorts, BARX1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of BARX1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where BARX1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BARX1 is over-expressed in tumor, although a few such as THCA and STAD show the opposite, repressed pattern.

LUSC, LUAD, and BLCA are the cancer types where BARX1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BARX1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	All	+2.986	<.001	8	view →
LUAD	Female	All	+2.557	<.001	8	view →
BLCA	Male	All	+2.249	<.001	8	view →
HNSC	Male	II,III,IV	+1.399	.004	6	view →
THCA	Male	II,III,IV	−0.571	<.001	4	view →
BRCA	Female	II,III,IV	+0.386	.028	4	view →
KIRC	All	All	+0.154	.007	4	view →
STAD	Female	All	−2.945	.040	3	view →
KIRP	All	All	+0.071	.031	3	view →
PAAD	All	All	+1.302	.048	2	view →
UCEC	All	All	+1.108	.009	2	view →
PRAD	All	All	+0.210	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

BARX1–LUSC

Open the LUSC breakdown →