BARHL1

Across TCGA patient cohorts, BARHL1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BARHL1-associated genes across cancer lineages are Myosin-IIa_pS1943, EGFR_pY1068, and Heregulin. Each is linked with BARHL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BARHL1-to-partner and partner-to-BARHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa_pS1943 grouped by BARHL1-low versus BARHL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BARHL1→partner) and Y-score (partner→BARHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa_pS1943 →	+0.300	+3.335	.005	.005	3	2
UCEC	EGFR_pY1068 →	-0.290	-3.000	.027	.036	3	1
UCEC	Heregulin →	-0.149	-3.000	.021	.036	3	1
UCEC	p62 Lck ligand →	+0.382	+2.817	.025	.036	3	1
UCEC	Rab25 →	-0.524	-3.321	.002	.010	3	1
UCEC	Shc_pY317 →	-0.215	-3.321	.006	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Myosin-IIa_pS1943 by BARHL1 expression — UCEC

Explore this box plot interactively →