BAP1

Across TCGA pan-cancer cohorts, BAP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated BAP1 data layer compared with 27 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher BAP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated BAP1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

PDAC, LUAD, and CCRCC are the cancer types where BAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.511	0.832	.008	36	view →
LUAD	DFS	Tertile	II,III,IV	0.673	0.957	.011	8	view →
CCRCC	OS	Quartile	III,IV	0.431	0.906	.012	7	view →
LSCC	DFS	Median	II,III,IV	0.843	0.562	.024	6	view →
UCEC	DFS	Quartile	All	0.833	0.969	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

BAP1–PDAC (DFS)

Open the PDAC breakdown →