BAP1

Across TCGA patient cohorts, BAP1 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BAP1-associated genes across cancer lineages are Bap1-c-4, Cyclin-B1, and p70-S6K. Each is linked with BAP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both BAP1-to-partner and partner-to-BAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bap1-c-4 grouped by BAP1-low versus BAP1-high in KIRC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BAP1→partner) and Y-score (partner→BAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	Bap1-c-4 →	-0.289	-3.584	<.001	.002	3	4
UCEC	Cyclin-B1 →	+0.432	+2.807	.016	.002	3	4
KIRC	p70-S6K →	+0.224	+1.892	<.001	.030	3	3
UCEC	Bcl-2 →	-0.268	-1.980	.015	.009	3	3
UCEC	P-Cadherin →	-0.135	-2.222	.003	.009	3	3
UCEC	ASNS →	+0.378	+2.247	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

Bap1-c-4 by BAP1 expression — KIRC

Explore this box plot interactively →