BAK1

Across TCGA patient cohorts, BAK1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BAK1-associated genes across cancer lineages are ATM, eIF4E, and JNK2. Each is linked with BAK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BAK1-to-partner and partner-to-BAK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by BAK1-low versus BAK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BAK1→partner) and Y-score (partner→BAK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.437	-2.222	.023	.011	3	2
UCEC	eIF4E →	+0.183	+3.013	.040	.018	3	1
UCEC	JNK2 →	+0.215	+3.026	.010	.018	3	1
UCEC	MEK1 →	+0.536	+3.807	<.001	<.001	3	1
UCEC	Notch1 →	+0.181	+2.594	.002	.006	3	1
UCEC	Rad50 →	-0.306	-2.906	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ATM by BAK1 expression — UCEC

Explore this box plot interactively →