BAK1

Across TCGA cell cohorts, BAK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,312 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BAK1-associated GO terms across cancer lineages are Negative regulation of release of cytochrome c from mitochondria, Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway, and Positive regulation of IRE1-mediated unfolded protein response. Each is linked with BAK1 in more than 12 cancer types. Because this analysis shows association rather than direction, both BAK1-to-partner and partner-to-BAK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of release of cytochrome c from mitochondria grouped by BAK1-low versus BAK1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BAK1→partner) and Y-score (partner→BAK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of release of cytochrome c from mitochondria →	+0.200	+1.042	<.001	<.001	3	13
BONE	Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway →	+0.185	+0.820	.003	.001	3	11
URINARY_TRACT	Positive regulation of IRE1-mediated unfolded protein response →	+0.206	+1.091	<.001	.002	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of IRE1-mediated unfolded protein response →	+0.125	+1.006	<.001	<.001	3	8
STOMACH	Establishment or maintenance of transmembrane electrochemical gradient →	+0.261	+0.644	.002	.004	3	8
LUNG_SCLC	Extrinsic apoptotic signaling pathway →	+0.058	+0.506	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,312 associations by consensus.

Negative regulation of release of cytochrome c from mitochondria by BAK1 expression — BONE

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