Across TCGA patient cohorts, BAG6 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BAG6-associated genes across cancer lineages are eEF2, Shc_pY317, and EGFR_pY1068. Each is linked with BAG6 in more than 1 cancer types. Because this analysis shows association rather than direction, both BAG6-to-partner and partner-to-BAG6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BAG6→partner) and Y-score (partner→BAG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.405	+2.000	.003	.010	3	2
UCEC	Shc_pY317 →	-0.207	-2.000	<.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.263	-3.459	.007	.005	3	1
UCEC	eIF4E →	+0.191	+2.000	.021	.030	3	1
UCEC	A-Raf_pS299 →	-0.148	-1.584	.001	.036	3	1
UCEC	GAPDH →	+0.448	+2.321	.033	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

BAG6 survival (RNA) · tumor vs normal (RNA) · all BAG6 data types