Across TCGA cell cohorts, BAG6 mutation is significantly associated with the RNA expression of many other genes, with 308 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BAG6-associated genes across cancer lineages are CLEC14A, OR6B1, and GALR3. Each is linked with BAG6 in more than 1 cancer types. Because this analysis shows association rather than direction, both BAG6-to-partner and partner-to-BAG6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BAG6→partner) and Y-score (partner→BAG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CLEC14A →	+0.013	+4.217	.007	.005	3	2
STOMACH	OR6B1 →	+0.020	+5.285	<.001	.003	3	2
LARGE_INTESTINE	GALR3 →	+0.067	+3.743	.006	<.001	3	2
LARGE_INTESTINE	ARPC1B →	-0.678	-2.541	.007	.005	3	2
LARGE_INTESTINE	PPP1R3D →	-0.474	-2.455	.007	.006	3	2
LARGE_INTESTINE	LARP1B →	+0.680	+3.459	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 308 associations by consensus.

Exploration

BAG6 survival (RNA) · tumor vs normal (RNA) · all BAG6 data types