BAG5

Across TCGA pan-cancer cohorts, BAG5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated BAG5 data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher BAG5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated BAG5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where BAG5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.902	0.680	.001	15	view →
CCRCC	DFS	Median	III,IV	0.827	0.529	.010	12	view →
PDAC	DFS	Median	III,IV	0.851	0.556	.026	3	view →
LSCC	DFS	Tertile	All	0.971	0.877	.033	3	view →
LUAD	OS	Tertile	III,IV	0.394	0.807	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

BAG5–HNSC (DFS)

Open the HNSC breakdown →