BAG5

Across TCGA patient cohorts, BAG5 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BAG5-associated genes across cancer lineages are ATM, 14-3-3_beta, and EGFR_pY1068. Each is linked with BAG5 in more than 1 cancer types. Because this analysis shows association rather than direction, both BAG5-to-partner and partner-to-BAG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by BAG5-low versus BAG5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BAG5→partner) and Y-score (partner→BAG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.475	-3.584	.005	.002	3	2
UCEC	14-3-3_beta →	-0.097	-3.295	.010	.009	3	1
UCEC	EGFR_pY1068 →	-0.276	-3.700	.003	.001	3	1
UCEC	A-Raf_pS299 →	-0.119	-2.459	.007	.019	3	1
UCEC	ERK2 →	+0.196	+1.765	.006	.014	3	1
UCEC	FoxM1 →	+0.223	+1.884	.021	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ATM by BAG5 expression — UCEC

Explore this box plot interactively →